Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
نویسندگان
چکیده
منابع مشابه
Volume Overload in Heart Failure
The burden of heart failure (HF) remains formidable in the US, with nearly one million annual hospital admissions and frequent outpatient visits to a variety of care providers. While HF outcomes have improved modestly over the past several decades, many patients still struggle to maintain a satisfactory quality of life. Implantable cardioverter– defibrillators have reduced the risk for sudden c...
متن کاملFish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
AIMS Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with omega-3 PUFA exerts metabolic and anti-inflammatory effects that could prevent left ventricle (LV) pathology; however, it is unclear whether these effects occur at clinically relevant doses and whether there are differences betwee...
متن کاملEffect of Chronic Pressure and Volume Overload
I NCREASE in chamber volume (and therefore increase in wall surface area) is an appropriate adaptation to an increased volume load.' Conversely, a small thick-walled chamber is better suited to deal with a pressure load.2-4 That the human heart so adapts itself to chronic volume and chronic pressure loads is evident from clinical experience and postmortem studies. However, actual measurements o...
متن کاملRV pressure overload: from hypertrophy to failure.
In pulmonary arterial hypertension (PAH), right ventricular (RV) adaptation is essential to overcome the chronic increases in RV pressure overload. Ultimately, RV compensatory mechanisms are not sufficient and patients succumb to RV failure. The processes underlying the transition of RV adaptation to RV failure are not well understood. In this review, we propose that important insights in RV ad...
متن کاملCardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy
Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein family, responsible for the transportation of fatty acids. It is considered to express mainly in adipose tissues, and be strongly associated with inflammation, obesity, diabetes and cardiovasculardiseases. Here we report that FABP4 is also expressed in cardiomyocytes and plays an important role in regula...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2017
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci81870